Bone Tumors
Classification/Bone Tumors

General Type	Benign Entity	Malignant Entity
Osseous Producing	Benign Osseous	Malignant Osseous Osteosarcoma (OS)
(Bone Producing) (Osteoid Producing)	Osteoma Osteoid Osteoma Osteoblastoma	Intramedullary Types Conventional OS (Most Common) Telangiectatic OS Low Grade Intraosseous OS Intracortical OS
Cartilage Producing	Benign Chondroid	Malignant Chondroid Chondrosarcoma (CS)
(Chondriod Producing)	Enchondroma Osteochondroma Periosteal Chondroma Chondroblastoma Chondromyxofibroma (CMF) Multiple Hereditary Exostoses (MHE) Enchondromatosis Mafucci’s Syndrome	Intramedullary Conventional CS Grade 1 Grade 2 Grade 3 Clear Cell CS Mesenchymal CS Dedifferentiated CS
		Juxtacortical/Surface Periosteal CS
		Secondary CS Osteochondroma Enchondroma MHE Enchondromatosis Mafucci’s Syndrome
Fibrous Producing	Benign Fibrous	Malignant Fibrous
(Fibrous Tissue Producing)	Nonossifying Fibroma Fibrous Dysplasia Desmoplastic Fibroma Benign Fibrous Histiocytoma Ossifying Fibroma	Fibrosarcoma Grade 1 (Low Grade) Grade 2 (Intermediate) Grade 3 (High Grade) Malignant Fibrous Histiocytoma (MFH) (aka: Myxoid Fibrosarcoma)
Small Round Blue Cell	Beningn Small Round Blue Cell	Malignant Small Round Blue Cell
(These tumors do not produce matrix; Non Matrix Producing)	Eosinophilic Granuloma (EG) (Infection can mimic a Small Round Blue Cell Tumor)	Ewing Sarcoma / PNET Lymphoma Myeloma
Vascular Origin	Benign Vascular	Malignant Vascular
(Blood Vessel Origin)	Hemangioma Lymphangioma	Hemangioendothelioma Hemangiopericytoma Angiosarcoma
Giant Cell	Benign Giant Cell	Malignant Giant Cell
	Giant Cell Tumor (GCT) Aneurysmal Bone Cyst (ABC)	Malignant Giant Cell Tumor
Muscle Origin	Benign Muscle	Malignant Muscle
		Leiomyosarcoma Rhabdomyosarcoma
Neurogenic	Benign Nervous	Malignant Nervous
(Nerve origin; Very rare to occur in bone)	Schwannoma (aka: Neurilemoma)	Malignant Peripheral Nerve Sheath Tumor (MPNST) (aka: Neurofibrosarcoma)
Fat Producing	Benign Fatty	Malignant Fatty
	Lipoma	Liposarcoma
Miscellaneous Origin/ Unknown Origin	Benign	Malignant
	Ganglion Unicameral/Simple Bone Cyst (UBC) Aneurysmal Bone Cyst (ABC) Liposclerosing Myxofibrous- Tumor (LSMFT)	Adamantinoma Synovial Sarcoma
Pediatric Bone Tumors	Benign	Malignant/Sarcomas
	Aneurysmal Bone Cyst (ABC) Chondroblastoma Enchondroma Enchondromatosis Eosinophilic Granuloma Fibrous Dysplasia Hemangioma Nonossifying Fibroma Osteoblastoma Osteochondroma Osteoid Osteoma Ossifying Fibroma Periosteal Chondroma	Ewing Sarcoma Lymphoma Osteosarcoma Primitive Neuro- ectodermal Tumor (PNET)